In vitro susceptibility of Haemophilus influenzae to trimethoprim-sulfamethoxazole.
نویسندگان
چکیده
Thirty-four strains of Haemophilus influenzae (20 ampicillin sensitive and 14 ampicillin resistant), mostly type b isolates from cerebrospinal fluid or blood, were tested for susceptibility to a combination of trimethoprim-sulfamethoxazole (TMP-SMZ) in a ratio of 1 part TMP to 19 parts SMZ. All strains were very susceptible to the TMP-SMZ combination, with minimal inhibitory concentrations ranging from 0.007-0.14 to 0.06-1.18 mug of TMP-SMZ per ml. There was little difference in the susceptibility of the ampicillin-sensitive and ampicillin-resistant strains to TMP-SMZ.
منابع مشابه
Elaboration of type b capsule by Haemophilus influenzae as a determinant of pathogenicity and impaired killing by trimethoprim-sulfamethoxazole.
In vitro, Haemophilus influenzae strains have two distinct patterns of susceptibility to trimethoprim-sulfamethoxazole (TMP/SMZ); strains with low minimum inhibitory concentration and high minimum bactericidal concentration (tolerant) and those with both low minimum inhibitory concentration and minimum bactericidal concentration (kill-sensitive). Tolerant H. influenzae strains were found to ela...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 6 6 شماره
صفحات -
تاریخ انتشار 1974